After his coronation, T'Challa began hunting down Ulysses Klaue, only to be confronted by his cousin Erik Killmonger, who sought the throne for himself. After a lengthy campaign, T'Challa defeated Killmonger and decided to introduce Wakandan technology to the United Nations.
Two years later, he assisted the Avengers in trying to stop Thanos and the Black Order from obtaining the Infinity Stones, resulting in a massive confrontation between the Black Order, the Avengers, and Wakanda's army. However, while T'Challa and his allies managed to kill off all of Thanos's forces, Thanos came to Wakanda. The Mad Titan completely overpowered T'Challa and the heroes and retrieved the Mind Stone, completing the Infinity Gauntlet. T'Challa disintegrated into ashes alongside Sam Wilson, Wanda Maximoff, Bucky Barnes and Groot when Thanos wiped out half of every civilization in the universe with the completed Infinity Gauntlet. However, T’Challa is survived by his sister Shuri and his mother Ramonda.